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It has also been demonstrated that the long non-coding RNA PWAR6, which is overexpressed in metastatic colorectal cancer tissues, functions as a competitive inhibitor of Keap1, thereby promoting the stabilization of NRF2

Oncogene 27 , 15271535 (2008)

Since proteasomal degradation typically yields small peptides ranging from 6-10 residues 16,17 , the proteasome is unlikely to generate the observed degradation products

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