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Carnitine octanoyltransferase (CrOT) is predominantly found in peroxisomes and plays a key role in the transfer of medium-chain acyl groups from the peroxisomes to the cytoplasm and mitochondria for further degradation [27]

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The FDA has not formally added ipamorelin to Category 1 as of June 2026

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Table 3 summarizes these therapeutic strategies, including natural compounds, supplements, natural extracts, and other intervention methods, along with their mechanisms of action