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Additionally, funding agencies can also consider funding for degradation and toxicity studies that use high dimensional techniques such as siRNA seq, mass cytometry, and special transcriptomics to demonstrate single cell and tissue level toxicity of degradation products

doi: 10.14348/molcells.2023.0028 131 SwerdlowN

Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production

A volume of ice-cold acetonitrile equal to four times the sample serum volume was then added and the sample vortexed vigorously for 30 s