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Additionally, Amodei & Lamb, 2013 found that making NRT available over the counter in the US did not meaningfully change smoking rates in the US, and that the proportion of smokers attempting to quit who use NRT is fairly small (8-21%)

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Also, cigarette smoke decreased the relative mRNA and protein expression of glutamate transporter1 (GLT-1) and the cystine-glutamate transporter (xCT) in the PFC and the NAc, while ASA treatment normalized their expression

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