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Primeau V, Coderre L, Karelis AD, Brochu M, Lavoie M-E, Messier V, et al

The tesofensine article covers a compound that approaches weight loss through neurotransmitter modulation, providing appetite suppression through a completely different mechanism than GLP-1 agonists

The compound was developed by the Australian biotech firm Metabolic Pharmaceuticals as a research tool to isolate the lipolytic signaling domain of growth hormone without the receptor-binding region responsible for its anabolic and glucose-handling effects