Key areas of investigation include: Gastrointestinal : Demonstrated protection against NSAID-induced ulcers, inflammatory bowel disease models, and esophageal damage in multiple animal studies Musculoskeletal : Accelerated healing of transected Achilles tendons, quadriceps muscles, and medial collateral ligaments in rat models Neurological : Neuroprotective effects in models of traumatic brain injury, nerve crush injury, and dopaminergic system damage Organ protection : Hepatoprotective, cardioprotective, and nephroprotective effects demonstrated in various toxicity models The primary limitation is that all evidence comes from animal models
Following this concussive-like brain injury, the decrease in NR2A expression in the younger brain is thought to contribute to the failure to show EE plasticity acutely (Giza et al., 2006)
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(2016) 41:E4655
Erdamar H, Cimen B, Glcemal H, Saraymen R, Yerer B, Demirci H
81,83 This observation suggested that immune responses induced by IC played dual roles, the enhanced immune responses not only targeted the virus but also targeted host hepatocytes harboring the virus