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Intranasal RNs significantly improved RGC survival at approximately half the oral dose, thereby minimizing systemic exposure

2009;13(2):R55

At 500 mcg per day, one vial lasts approximately 3 months

doi: 10.1016/j.cell.2020.08.051 203 WimmersFDonatoMKuoAAshuachTGuptaSLiCet al

Besides the acute phase gastrointestinal effects which may lead to up to 10% of people discontinuing the drugs, there are other potential GI side effects of obstruction, excessive loss of muscle mass, and potentially association with some eye disease adverse events

3 , 1N HCl and saturated brine for three times, combine the organic phases, add anhydrous sodium sulfate, dry and filter, and remove the solvent