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Bioavailability is the deciding factor, especially for glutathione, which needs liposomal protection to be effective

In some embodiments, the otic formulation or composition comprises about 10% by weight of the poloxamer

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However, factors like aging, stress, and environmental toxins can deplete glutathione levels, making supplementation beneficial

Biochimica Et Biophysica Acta (BBA)-Bioenergetics