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Tirzepatide carries a boxed warning about thyroid C-cell tumors observed in rodent studies and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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Similarly, mutations in the Foxp3 gene, which controls Treg development, cause IPEX syndrome, a devastating autoimmune condition affecting multiple organ systems

Session: 4560 minutes