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Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase

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Indeed, WT and Myd88 / , but not Nlrp3 / macrophages, presented increased tricarboxylate transport protein (Slc25a1) mRNA, a citrate carrier protein necessary for the generation of mitochondrial oxidative stress upon uric acid stimulation 63,64 (Fig

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1 RA primarily affects the lining of the synovial joints and can cause progressive disability, premature death, and socioeconomic burdens