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This chronic sympathetic activation not only causes anxiety, insomnia, and rapid heart rate, but it also signals to the innate immune system that the body is under constant threat, further provoking mast cell degranulation

On the basis of the scoring values of the binding energy obtained from docking, compounds AD were further inspected for their interactions with the target in terms of hydrophobic, hydrogen, and other bonding types, as shown in Fig

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GSTs are phase 2 enzymes, ubiquitously distributed in the cell