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Pharmacokinetic study and optimal formulation of new anti-Parkinson natural compound schisantherin A

Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J et al (2002) Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

New basic and clinical research is clarifying the mechanistic relevance and therapeutic feasibility of multiple targets within the glutamate system for novel drug discovery, including NMDA and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, metabotropic glutamate receptors, and other key regulatory proteins such as glycine transporter 1 and excitatory amino acid transporters

doi: 10.1371/journal.pone.0270351 159 LeeJHongYSJeongJHYangEJJhunJYParkMKet al

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