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Dephosphorylation of fructose-1,6-bisphosphate back to fructose-6-phosphate does not occur, considering that in most cancers the expression of fructose-1,6-bisphosphatase is strongly diminished 117

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10.1074/jbc.M503075200 Veeravalli K, Boyd D, Iverson BL, Beckwith J, Georgiou G: Laboratory evolution of glutathione biosynthesis reveals natural compensatory pathways

Furthermore, the integration of omics technologies and biomarker-based screening strategies may aid in identifying patient subgroups most likely to benefit from natural product-based interventions, ultimately enabling more precise and personalized IVF management for DOR patients

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Mirmiranpour, A