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It received GRAS status from the U.S

High doses may cause temporary headaches due to increased NAD+ turnover and mitochondrial activity

It is sold exclusively for laboratory research and is not FDA-approved for any clinical application

TB4 led to a notable 45% reduction in median healing in patients whose wounds fully healed, compared to placebo [34]

Because no studies have evaluated potential risks, such as effects on the fetus or pregnancy outcomes, clinicians advise against NAD+ therapy during pregnancy out of an abundance of caution

Thinking clears: The foggy, hard-to-concentrate feeling often improves as levels come back up