Among men, the pooled relative risk for coronary heart disease was 1.48 for smoking one cigarette per day and 2.04 for 20 cigarettes per day, using all studies, but 1.74 and 2.27 among studies in which the relative risk had been adjusted for multiple confounders
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Corey CG, Holder-Hayes E, Nguyen AB, et al
Findings show that smoking induces oxidative stress and inflammation that damage the endothelium, compromising vascular function almost immediately ( 49 )
This experience is well documented, but very little specific research has been carried out
The evaluation of the intensity of tobacco flavor based on expert panel can be performed using the quantitative descriptive analysis (QDA) method 9-12