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The simplest way to think about them is in two buckets: stomach symptoms during dose escalation, and a separate skin-sensation signal at the highest dose in Phase 3

What matters is the totality of the circumstances: who is buying the product, how it is being marketed, what the seller knows about intended use, and whether the product is being sold alongside dosing instructions, syringes, bacteriostatic water, or other indicators of human use

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For the GLP-1 comparison head-to-heads, see the semaglutide protocol, tirzepatide protocol, and retatrutide protocol