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The most common adverse effects of metformin are gastrointestinal, including diarrhea, nausea, abdominal discomfort, and metallic taste, occurring in up to 30% of patients

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The proteins released from the intermembrane space include cytochrome c, which is required for the formation of a complex with dATP and apoptotic protease activating factor 1, known as the apoptosome (Morse et al., 2024

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