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In some embodiments, the deliverable osmolarity of any formulation described herein is designed to be isotonic with the targeted otic structure (e.g., endolymph, perilymph, or the like)

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Considering the sensitivity of copper peptides to pH (4.67.0) and the viscosity requirement of delivery agents, we selected CaT-1:1 (anion:cation molar ratio of 1:1) for further investigations

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For people who rotate between multiple injection sites , the thigh is often the most practical starting point