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Phase 3 Standard Cagrilintide Dose Based on Phase 2 findings, the standard cagrilintide dose for Phase 3 trials was established at: 2.4 mg administered subcutaneously once weekly This dose represents the optimal balance between: Efficacy : Substantial weight loss and metabolic improvements Safety : Manageable side effect profile Tolerability : Acceptable patient adherence rates The REDEFINE 1 trial, which evaluated cagrilintide in combination with semaglutide (CagriSema), used this 2.4 mg dose and demonstrated remarkable results

Wasitaatmadja, MD, as the initiator of the study

stable for up to 24 months [16]

Mazdutide is another GLP-1/glucagon dual agonist showing promising results

Aoki H, Ozeki Y, Yamada N

Biological effects of Epitalon