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239 Interestingly, -catenin can also be activated by signals besides Wnt, including HGF, EGF, and protein kinase A (PKA)

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In the altered scenario of cholestasis, the retention of more hydrophobic bile salts, such as the glyco- and tauro-conjugates of deoxycholate, plays a major part in the onset of liver injury, causing hepatotoxicity due to mitochondrial dysfunction and production of ROS, with consequent oxidative damage [181,182]