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Convincing evidence indicates that -syn undergoes O-GlcNAc modification at multiple residues in vivo [136, 138]

Implementing periodic washout phasessuch as 5 days on, 2 days off, or alternating weekspreserves receptor sensitivity while maintaining neuroplastic stimulus across extended protocols

It is not subject to feedback inhibition by glutathione (GSH) and its substrates gamma-glutamylcysteine (GGC) and glycine are rapidly ligated to form glutathione (GSH)

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In advanced IDD, ferroptosis switches from a permissive state to a dominant execution program in subsets of disc cells