Limited research exists on topical copper peptide use during pregnancy
(Source for lack of human PK data)
Headache: The most commonly reported adverse event was headache, characterized as mild to moderate in severity
The neuroprotective mechanism of HDACi was linked with upregulation of expression of NGF, activation of TrkA phosphorylation, phospho-protein kinase B (p-AKT), NFB, and B-cell lymphoma 2 (Bcl-2) cell survival factors, while the downregulation of phospho-JNK, p75 neurotrophin receptor (NTR), and Bcl-2-associated X protein apoptosis factors (Wu et al., 2013) studied the effect of VPA, TSA, 4-phenyl butyric acid (4-PBA), and nicotinamide in astrocyte and dopamine neuron glial culture
PMID 39994346
The increase in leu-enkephalin levels adds another anxiolytic dimension