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Research suggests that calcium deficiency may be a common concern for women with PCOS, although the exact relationship between calcium status and insulin resistance remains uncertain [141]

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Immunohistochemistry of brain tissues from mice treated with GHK showed evidence of decreased inflammation and increased labeling of histone deacetylase 2, suggesting that in addition to an anti-inflammatory effect, GHK may be triggering an epigenetic pathway in the amelioration of cognitive impairment in aging mice

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Preliminary testing to understand patient-specific gene expression profiles and/or genomic sequencing to reveal genotypic nucleotide variants may assist the precise implementation of such strategies