4.1 Clinical relevance of the CLP model The CLP model was selected for its unique ability to recapitulate core clinical features of SAE: polymicrobial sepsis, hippocampal neurodegeneration, and chronic cognitive impairment ( 4.2 Microglia-mediated oxidative neuronal injury Microglial activation initiates neuronal damage, and a previous study revealed that the microglial inhibitor minocycline reduces neuronal apoptosis ( in vivo oxidative stress ( Mechanistically, a microglial inflammation-oxidative stress feedforward loop perpetuates injury: Activated microglia secrete neurotoxins, impairing neuronal mitochondrial function and antioxidant capacity (such as GPX4), thus increasing ROS leakage
Myth: "Glutathione is only for liver health." Fact: While the liver uses a high concentration of glutathione for detoxification, every cell in your body needs it to manage oxidative stress
Mol Cell Biol 1993;13:46008
Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology
But what if we told you that testosterone has just as much if not more impact on your mental health
TMG for glutathione synthesis
