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Senolytics under scrutiny in the quest to slow aging

doi: 10.3389/fphys.2022.1052429

Dysbiotic oral microbiota characterized by significantly reduced Firmicutes and Bacteroides levels alongside increased Actinomycetes in children with cerebral palsy and epilepsy (CPE) can translocate to the intestinal tract, inducing gut microbiota dysbiosis where Bifidobacterium, Bacteroides , and Prevotella emerge as dominant genera (Huang et al., 2022), Notably, in PD, periodontitis-associated oral dysbiosis occurs independently of gut microbial changes, underscoring disease-specific oral effects (Yay et al., 2024)

Feichtmeier NS, Walther P, Leopold K

Our results suggest that multilayer integration captures more critical features than single-dataset analyses, identifying nine key metabolites versus only two in univariate analyses