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When intestinal barrier integrity is compromised or permeability increases, LPS enters the circulation via the paracellular pathway or through lipoprotein-mediated transcellular transport

For example, a study compared the effects of administration of NAC 0.6 g + folic acid 500 g/day in a group of 80 patients with a history of RM with an aged-matched group of 86 patients treated with folic acid 500 /day alone (204)

Recently, increasing attention has been focused on the application of metal complexes to catalyze the transformation of biological essential biomolecules into (cytotoxic) products or products that ultimately lead to cell death

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