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Of the 2,570 MOUNJARO-treated patients who developed anti-tirzepatide antibodies during the treatment periods in these seven trials, 2% and 2% developed neutralizing antibodies against tirzepatide activity on the GIP or GLP-1 receptors, respectively, and 0.9% and 0.4% developed neutralizing antibodies against native GIP or GLP-1, respectively

Results vary based on individual metabolism, dosage, frequency, and lifestyle habits

Elevated insulin blocks fat mobilization, rendering the peptide less effective

Excretion Mainly excreted through urine and bile, with a half-life of approximately 6 to 8 hours

Healthcare professionals should maintain awareness that GLP-1/GIP medicines, whilst highly effective for their intended indications, require holistic management addressing not only glycaemic control and weight but also nutritional status and overall metabolic health