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Eumelanin to Pheomelanin: Glutathione converts darker eumelanin to lighter pheomelanin, lightening skin

Notably, alterations in oligodendrocyte gene expression emerge early in PD, even before overt dopaminergic degeneration, pointing to their role in initial disease mechanisms

It has been reported that across Europe 35% of adolescents of the general population presented folate insufficiency and 15% deficiency while only 2% had low vitamin B 12 levels [35, 36], though this contrasts with a previous review of European studies which found no folate or B 12 deficiencies in blood levels, but did not report data regarding insufficiencies [37]

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