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Oxidative stress serves as a primary activator of the NRF2 pathway, initiating the transcription of antioxidant and detoxification genes that help restore redox balance

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A 6-8 week escalation period between dose increases (instead of 4 weeks) is common in patients over 65

Hopefully, the rapid interest in the study of HDAC inhibitors will shed some light on the mechanism of action of these inhibitors and give us directions to combat neurodegenerative diseases

[33] Disclaimer: These statements have not been evaluated by the Food and Drug Administration

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