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Hamad, M., Shelko, N., Kartarius, S., Montenarh, M

Dickkopf (DKK)-1 suppresses prostaglandin endoperoxide synthase (PTGS)-2-induced macrophage and neutrophil recruitment to lung metastases by antagonizing cancer cell non-classical WNT/Planar cell polarity (PCP)-RAC1-JNK signaling, whereas it encourages breast-to-bone metastasis by modulating classical WNT signaling of osteoblasts (99)

Adjustments may be made to the treatment plan as needed, such as modifying dosages, changing peptide types, or altering the administration schedule to enhance the therapys success.