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Across multiple animal studies, commonly scaled ranges often cluster between 1 and 4 mcg per kilogram, with higher experimental rodent models occasionally translating closer to 57 mcg per kilogram

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While the implications for SARM1 in regulating axonal fate are well-established, the sensing mechanisms of this protein complex toward NAD + , NMN, or even possibly toward other NAD + metabolites are not fully understood, and may suggest that also the other NAD + metabolites could regulate more biological processes than initially thought 54

doi: 10.1515/hsz-2016-0202 90 FraternaleA.PaolettiM

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