In general, NUPR1 is critical in regulating mitochondrial-related ferroptosis, either genetic or pharmacological inhibition of NUPR1 presents tumor-killing activity
It plays a central role in building and maintaining fat-free muscle mass
Together, increased intraplaque cellular death and dysfunctional efferocytosis as a result of G6PD-d may accelerate plaque growth, necrotic core formation and the development of an inflammatory plaque microenvironment 106,107 (Fig
However, there are also cases when additional factors such as lack of sleep, poor diet, and deficiency of other vitamins like iron, folate, and others, contribute to the issue
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