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Recent work using chemical library approaches to identify compounds that inhibit protein degradation have led to the realization that the polyubiquitin chain itself can be a drug target

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J Appl Physiol 63:152157 Huang J, Philbert MA (1995) Distribution of glutathione and glutathione-related enzyme systems in mitochondria and cytosol of cultured cerebellar astrocytes and granule cells

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We showed that GDH1 knockdown significantly reduces intracellular -KG abundance in several liver and lung cancer cell lines and GDH1 knockdown also reduces -KG levels in certain breast cancer cells (MDA-MB231), HEL and K562 leukemia cells and brain tumor cells 19,21

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doi: 10.1016/j.molcel.2018.10.042 15 YanBAiYSunQMaYCaoYWangJet al

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