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Thus, cystine starvation induces a stress signal of amino acid limitation through GCN2-eIF2-ATF4 branch in the ISR but not ER stress in HepG2 cells

Trimethyllysine Hydroxylase (TMLH) The biosynthetic pathway begins with the methylation of lysine residues in proteins to form N6-trimethyllysine (TML)

Gluathione is a tripeptide composed of cysteine, glycine and glutamic acid

their reduction is achieved by Trx

Glutathione (70-18-8) inherently contains an SH groupand can smell like rotten eggbut our model interestingly predicted it as Yeast (0.999, ST-LGBM), suggesting a fermentationlike nuance rather than raw sulfur

in 1976 [3]