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The effects of FGF23 are exerted primarily within the kidney where its actions result in increased phosphate excretion (decreased phosphate reabsorption) and suppression of calcitriol synthesis via inhibition of the expression of the CYP27B1 gene that encodes the PTH-inducible 1--hydroxylase enzyme

Prog Neuropsychopharmacol Biol Psychiatry (2013) 46:22435

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Several other clinical medications including anti-adrenergic (such as salbutamol, salmeterol, and formoterol), 101 HIV protease inhibitors, 102,103 atypical antipsychotics 104 and some exogenous insulin 105 that may improve IR because of the disordered insulin signaling

Bishop, S