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GSTM1 vs GSTT1: Different Enzymes, Overlapping Roles GSTM1 and GSTT1 are structurally related but belong to different GST subfamilies mu (GSTM) and theta (GSTT) with overlapping but not identical substrate profiles in estrogen metabolism: GSTM1 (Glutathione S-Transferase Mu 1) is highly expressed in liver, lung, and other metabolically active tissues

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