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Scientific studies and clinical practice show that B12 and Folate supplement may provide the following benefits: Energy Relief from pins and needle sensation in the feet and hands Stronger muscle Resolution of sore tongue Improvement in appetite Better balance and gait Improved memory Lowering of Homocysteine levels when vitamin B12 is given in combination with Folic acid and Vitamin B6, which may translate into reduced risk of heart disease and stroke

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AIDS, 22 (14), 1719-1728