Hoboken, NJ: John Wiley & Sons
& Perkins, A
These pathways remain early-stage research targets
Pediatr Crit Care Med 13(Suppl 1):S1S82 Kochanek PM, Jackson TC, Ferguson NM, Carlson SW, Simon DW, Brockman EC, Ji J, Bayir H, Poloyac SM, Wagner AK, Kline AE, Empey PE, Clark RS, Jackson EK, Dixon CE (2015) Emerging therapies in traumatic brain injury
Efficacy of N-acetylcysteine on prevention of antituberculosis drug-induced hepatotoxicity
When to Suspect APD APD should be suspected when: Skin symptoms recur monthly despite standard dermatologic treatment Symptoms reliably worsen before menstruation Reactions appear after starting progesterone or progestins Antihistamines provide partial but not complete relief Related: Histamine Intolerance: What It Is & What to Do About It APD Causes and Risk Factors APD develops due to an autoimmune response to progesterone, though the exact mechanism of this hypersensitivity is not fully understood