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Introduction Traumatic brain injury (TBI) is a general term for pathological or structural changes in the brain caused by impact, bumps, penetrating injuries, or blasting under external forces ( In the acute phase, moderate and severe TBI often cause intracranial hemorrhage, and half of the TBI patients may suffer from traumatic cerebral hemorrhage in addition to the primitive hematoma that causes compressive damage to brain tissue (Rosenfeld et al., 2012)

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-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase

Of note, cartilage created by FOXO4-DRI pretreated chondrocytes displays a lower senescence level than that from the untreated counterparts