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The pathogenesis of ischemia reperfusion injury begins with a hypoxic insult to the vascular endothelium which further demonstrates protective responses [28]

It is central to the neutralization of reactive oxygen species (ROS), detoxification of heavy metals, and regeneration of other antioxidants like Vitamins C and E

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Clin Chem 36 : 297303 Roe CR, Cederbaum SD, Roe DS, Mardach R, Galindo A, Sweetman L 1998 Isolated isobutyryl-CoA dehydrogenase deficiency: an unrecognized defect in human valine metabolism

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Nutritional sources The body can make it itself, so dietary sources are less important