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(3) Inhibiting Adipose Tissue Inflammation and Improving the Adipose Microenvironment In obesity, adipose tissue develops chronic lowgrade inflammation with abundant release of proinflammatory factors (such as TNF and IL6), disrupting the adipose microenvironment, further worsening fat metabolic abnormalities and insulin resistance, and forming a vicious cycle

IGF-binding protein-2 protects against the development of obesity and insulin resistance

Conflict of interest The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

Vitamin D plays a crucial role in supporting a healthy immune system, promoting bone health, and regulating hormonal balance

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FACT 5 OF 6 Check methylmalonic acid (MMA) for early detection MMA is a more sensitive marker than serum B12