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GSH-dependent protein de-nitrosylation occurs through a nitrosylation exchange mechanism that generates GSNO, which can be a substrate of the enzyme S-nitrosoglutathione reductase (GSNOR) that finally produces GSSG and ammonia (NH 3 ) [38,39,40]

Chapman, I

Barisic I, Balenovic D, Klicek R, Radic B, Nikitovic B, Drmic D, et al

Exp Lung Res

The body is unable to remove them efficiently, so they accumulate as biological waste that disrupts tissue homeostasis and accelerates degenerative changes

After DNA cleavage, the miRNA hybridises with a detection hairpin immobilised on a graphene oxide electrode, which produces an ECL signal that can be quantitatively measured [112, 114, 115]