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The reason is because these two work through overlapping biological pathways

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Dermatol 162, 43541

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Caffeic acid and its derivatives can block pro-angiogenic signaling: caffeic acid phenethyl ester (CAPE) has been reported to suppress STAT3-mediated VEGF expression, inhibiting tumor angiogenesis in renal carcinoma models

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Hand 15 , 776779 (2020)

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Notably, it resisted enzymatic degradation in vivo and significantly alleviated DSS-induced colitis in murine models

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It drives the transition from proliferation to differentiation and increases the number and length of multinucleated myotubes in a dosedependent manner.The mechanism is mainly related to NNMT inhibition, restored NAD levels, and activation of the SIRT1PGC1 pathway

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