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References Double-blinded comparison of diphenhydramine versus lidocaine as a local anesthetic The objective of this study was to evaluate the efficacy, onset of action, duration of action, and side effects of 1% diphenhydramine compared with 1% lidocaine when used as a local anesthetic agent

all of which are have been implicated in migraine pathology (Sun-Edelstein 2009b)

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Antimicrobial activity: Early studies have also noted activity against pathogens including Staphylococcus aureus and Candida albicans, an area that continues to attract research interest

Some researchers transition to maintenance-dose tirzepatide (typically 2.5-5mg weekly) indefinitely rather than stopping completely