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Furthermore, since estrogen receptors are ubiquitously located, estrogen-mediated signals modulate the biology of several tissues and organs, including the central nervous system
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Clinical mycology: Understanding pathogenesis, diagnosis, and antifungal strategies for invasive fungal infections: A review
Oral drugs undergo what is known as first-pass metabolism. First-pass metabolism is when the concentration of a drug, specifically when administered orally, is significantly reduced before it reaches systemic circulation
Converging evidence also suggests that non-responsiveness to traditional antidepressants is associated with heightened inflammation, underscoring the clinical relevance of this pathway [273]
Additionally, hyperphosphorylation and aggregation of neurofilaments (NFs) are observed in ALS pathology [160], and NFs are known to be modified by O-GlcNAc [161]
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