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Specifically, the only RCT aiming to investigate the BW lowering efficacy of mazdutide in patients without T2D was limited to Chinese patients and referred to different cut offs for the definition of obesity (BMI 28 kg/m 2 ) 49
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Originating from the cholesterol molecule, various biochemical transformations lead divergently to a large number of end products, which exert their actions via nuclear receptors and in some cases via receptors on cell membranes
Tubulin expression was detected on the same PVDF membrane using anti--tubulin specific monoclonal antibody (1 g/ml Sigma-Aldrich, Ont., CA), followed by HRP-conjugated goat anti-mouse IgG (1:5000 (v/v), BioRad, Ont., CA)
This targeted distribution contributes to the favorable side effect profile relative to systemic weight loss interventions like stimulants