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However, under defined pathophysiological stresses, including inflammatory cues, metal overload, cysteine deprivation, or drug exposure, GSH oxidation and thiol chemistry may become coupled to metal redox cycling and mitochondrial damage amplification, thereby increasing susceptibility to forms of regulated cell death such as ferroptosis and cuproptosis

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This includes: Those who have had allergic reactions to vitamin B12 or cobalt before People with certain health conditions, like Lebers disease Getting a full medical history and talking to a doctor before starting vitamin B12 injections is very important

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doi:10.1007/BF02002806