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A 2024 randomized controlled trial (RCT) with 60 women (ages 40-65) applied 0.1% GHK-Cu cream twice daily for 12 weeks, yielding 31% wrinkle reduction (visia analysis) and 28% improved skin elasticity versus placebo (Kim et al., 2024)

Conversely, inhibitors of PD-1/PD-L1 can selectively attach to either PD-1 or PD-L1, thereby interfering with the PD-1/PD-L1 interaction

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a small molecule that remains preclinical and not approved

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