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Brozoski TJ, Caspary DM, Bauer CA, Richardson BD

doi: 10.1016/j.cell.2019.04.024 49 ShimadaKSkoutaRKaplanAYangWSHayanoMDixonSJet al

Subcutaneous planning from a 50 mg vial reconstituted with 3.0 mL BAC water (~16.7 mg/mL) Phase Days 12 (tolerance) Daily dose 2.5 mg once daily Units on U-100 syringe 15 units Volume 0.15 mL Phase Days 3+ (standard) Daily dose 5 mg once daily Units on U-100 syringe 30 units Volume 0.30 mL Phase Split option (BID) Daily dose 2.5 mg twice daily Units on U-100 syringe 15 units each Volume 0.15 mL each Subcutaneous doses are much smaller than oral doses because of injection volume limits and because direct subQ absorption skips the gut

Patients often notice better energy, improved recovery, and more stable metabolism, which helps them stay consistent with exercise and healthy habits

Am J Ther 12:5666 Farrell G, Cooksley W, Powell L (1979) Drug metabolism in liver disease: activity of hepatic microsomal metabolizing enzymes

Instruct nursing mothers to seek immediate medical care if they notice these signs (see PRECAUTIONS, Nursing Mothers)