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However, our proposal to synthesize a peptide that would inhibit the release of gonadotropins was initially met by much skepticism because, at that time, few effective inhibitors had already been developed

10.1182/blood-2012-02-412080 65 KusakabeJ.HataK.TamakiI.TajimaT.MiyauchiH.WangY.et al (2020)

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2016;3(2):e1091059.[DOI] 40

The application of NaBPC1 57 (10 g, 10 ng/kg b.w.), propranolol (10 mg/kg b.w.), and ranitidine (10 mg/kg b.w.) (control rats received an equivolume of saline 5.0 ml/kg), either intragastrically or intraperitoneally, was conducted either prophylactically (10 days before alcohol initiation) or as a co-treatment together with alcohol or therapeutically (starting at the end of a two month period, i.e